12/9/2022 0 Comments Hidata mac![]() Among the four naturally-occurring amino acid combinations comprising QQ, MQ, LQ, and LM, the number of viruses with LM accounted for 79.64% of the sublineage h9.4.2.5 and the rescued virus with LM exhibited absolute advantages of in vitro and in vivo replication and transmission. They not only cause serious economic damage to the global poultry industry, but also occasionally pose substantial threats to human health.Ĭollectively, these data demonstrate that residues 226 and 227 are under selective pressure and their synergistic regulation of receptor avidity and antigenicity is related to the evolution of circulating H9N2 viruses.Īvian influenza viruses (AIVs) belong to the genus Alphainfluenzavirus of the virus family Orthomyxoviridae. ![]() H9N2 is one of the most widespread subtypes of the AIV family, which has been found in wild birds and as an enzootic pathogen in poultry across much of Asia and parts of Africa since 1966. ![]() For decades, H9N2 viruses have evolved to break through the interspecies barrier transmitting to pigs, dogs, horses, mink, pika, and bats. It is noteworthy that the long-term prevalence favors the interspecies transmission of H9N2 viruses from avian species to humans. From July 1998 to August 2020, at least 69 people worldwide were infected with H9N2 viruses. Retrospective serosurveys also revealed high seropositivity rates for H9N2 antibodies among poultry workers. ![]()
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